Vorinostat oral capsule
Vorinostat is a chemotherapy medication that treats cutaneous T-cell lymphoma. This is a rare type of blood cancer that affects your skin. This medication comes as a capsule that you can take with a glass of water and food as directed.
What is this medication?
VORINOSTAT (vor IN oh stat) is a chemotherapy drug. It is used to treat cutaneous T-cell lymphoma (CTCL).
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
COMMON BRAND NAME(S): Zolinza
What should I tell my care team before I take this medication?
They need to know if you have any of these conditions:
history of blood clots
history of irregular heartbeat
take medicines that treat or prevent blood clots
an unusual or allergic reaction to vorinostat, other medicines, foods, dyes, or preservatives
pregnant or trying to get pregnant
How should I use this medication?
Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Do not chew, crush, or open the capsules. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
What may interact with this medication?
Do not take this medicine with any of the following medications:
This medicine may also interact with the following medications:
certain antibiotics like clarithromycin, erythromycin, levofloxacin, mefloquine
medicines for depression, anxiety, or psychotic disturbances
medicines for irregular heart beat
medicines for nausea/vomiting like dolasetron, ondansetron, palonosetron
medicines for numbness or sleep during surgery
medicines that treat or prevent blood clots like enoxaparin, heparin, ticlopidine, warfarin
other cancer treatments like dasatinib, lapatinib
other medicines that prolong the QT interval (cause an abnormal heart rhythm)
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medication?
You will need blood work done while you are taking this medicine.
Talk to your doctor about how many glasses of water to drink each day. It is important to drink plenty of fluids and to avoid dehydration.
If the capsules of this medicine is broken or opened, do not touch the capsules or the powder contents of the capsules. If the powder gets on your skin or in your eyes, wash the area well with plenty of water. Call your doctor.
Do not become pregnant while taking this medicine or for a least 6 months after stopping it. Women should inform their healthcare professional if they wish to become pregnant or think they might be pregnant. Men should not father a child while taking this medicine or for at least 3 months after stopping it. There is a potential for serious effects to an unborn child. Talk to your healthcare professional for more information.
Do not breast-feed an infant while taking this medicine or for at least 1 week after stopping it.
This medicine may make it more difficult to get pregnant. Talk to your healthcare professional if you are concerned about your fertility.
What side effects may I notice from receiving this medication?
Side effects that you should report to your doctor or health care professional as soon as possible:
allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
change in the amount of urine
fast, irregular heartbeat
feeling faint or lightheaded, falls
fever or chills, sore throat
increased hunger or thirst
pain, swelling, warmth in the leg
problems with balance, talking, walking
swelling of feet, legs
unusual bleeding or bruising
unusually weak or tired
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
changes in taste
loss of appetite
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medication?
Keep out of the reach of children.
Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.