Acidulated Phosphate Fluoride Dental Gel

Medically reviewed by Health Library. Date Last Reviewed: 22/05/2023

Acidulated Phosphate Fluoride Dental Gel

What is this medication?

ACIDULATED PHOSPHATE FLUORIDE (uh SID yoo lay ted FOS fate FLOOR ide) prevents tooth decay. It may also be used to reduce gum and tooth sensitivity. It works by making your teeth stronger. Fluoride is a mineral that plays an important role in the health of your teeth and bones.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

COMMON BRAND NAME(S): 60 Second, APF, Carles 60 Second APF, Dental Resources APF, Fluorident, Minute-Gel, Nupro APF Gel, Perfect Choice One Minute APF, Quik-Set, Topex 00:60 Second APF

What should I tell my care team before I take this medication?

They need to know if you have any of these conditions:

Porcelain or ceramic dentures

An unusual or allergic reaction to fluoride, other medications, foods, dyes, or preservatives

Pregnant or trying to get pregnant


How should I use this medication?

This medication is applied to the teeth. Follow the directions on the prescription label. Brush with your normal toothpaste and rinse thoroughly. Apply a ribbon of this medication to teeth using a toothbrush or mouth tray for at least one minute. Spit out the gel and do not eat, drink, or rinse for 30 minutes for best results. Children 6 to 16 years of age should rinse their mouth thoroughly with water after use. DO NOT SWALLOW the dental gel. Do not use more often than directed.

Talk to your care team about the use of this medication in children. While this medication may be prescribed for children as young as 6 years for selected conditions, precautions do apply.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.

NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

If you miss a dose, use it as soon as you can. If it is almost time for your next dose, use only that dose. Do not use double or extra doses.

What may interact with this medication?

Interactions are not expected. Do not use any other dental products without asking your care team.

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medication?

This product may reduce your risk of dental cavities. Continue to follow proper dental hygiene, such as regular brushing and flossing. See your care team for regular check-ups.

If this gel is accidentally swallowed, contact a Poison Control Center immediately. Also, prolonged daily ingestion can cause abnormal tooth enamel. Report any signs of abnormal tooth color or staining or spotting of the teeth right away.

What side effects may I notice from receiving this medication?

Side effects that you should report to your care team as soon as possible:

Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat

Change in tooth color

Side effects that usually do not require medical attention (report to your care team if they continue or are bothersome):



Irritation inside the mouth or throat


This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medication?

Keep out of the reach of children and pets.

Store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Throw away any unused medication after the expiration date.

NOTE: This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

This information is not intended as a substitute for professional medical care. Always follow your healthcare professional's instructions.